Selective oxidation in vitro by myeloperoxidase of the N-terminal amine in apolipoprotein B-100

Selective oxidation in vitro by myeloperoxidase of the N-terminal amine in apolipoprotein B-100

In contrast to the multiple low abundance 2,4-dinitrophenylhydrazine-reactive tryptic peptides formed by oxidation of LDL with reagent HOCl in vitro, myeloperoxidase-catalyzed oxidation produces a dominant product in considerably greater yield and selectivity. This modified peptide had a single amin...

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Bibliographic Details
Main Authors: Chao-yuh Yang, Jin Wang, Andrew N. Krutchinsky, Brian T. Chait, Joel D. Morrisett, Charles V. Smith
Format: Article
Language:English
Published: Elsevier 2001-11-01
Series:Journal of Lipid Research
Subjects:
2,4-dinitrophenylhydrazine
low density lipoprotein oxidation
protein carbonyl
protein oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520315157

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http://www.sciencedirect.com/science/article/pii/S0022227520315157

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