Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes

Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes

Brown adipose tissue (BAT) represents a promising agent to ameliorate obesity and other metabolic disorders. However, the abundance of BAT decreases with age and BAT paucity is a common feature of obese subjects. As brown adipocytes and myoblasts share a common Myf5 lineage origin, elucidating the m...

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Bibliographic Details
Main Authors: Chao Wang, Weiyi Liu, Yaohui Nie, Mulan Qaher, Hannah Elizabeth Horton, Feng Yue, Atsushi Asakura, Shihuan Kuang
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:EBioMedicine
Subjects:
MyoD
Myogenesis
Repressor
Adipogenesis
Brown adipocytes
CRISPR-Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417300191

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http://www.sciencedirect.com/science/article/pii/S2352396417300191

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