Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation

Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation

Cyclosporin A (CyA) induces gingival overgrowth via its stimulatory effects on expression of transforming growth factor-beta1 (TGF-β1) and collagen. It is not known whether CyA has a direct effect on gingival fibroblasts or induces its effect indirectly via stimulation of myofibroblast tran...

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Bibliographic Details
Main Authors: Lays Martin Sobral, Michele Gassen Kellermann, Edgard Graner, Hercilio Martelli-Junior, Ricardo Della Coletta
Format: Article
Language:English
Published: Sociedade Brasileira de Pesquisa Odontológica 2010-06-01
Series:Brazilian Oral Research
Subjects:
Gingival overgrowth
Cyclosporine
Fibroblasts
Transforming growth factor beta
Connective tissue growth factor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200010

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200010

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