Chromatinised Protein Kinase C-theta: can it escape the clutches of NF-kB?
We recently provided the first description of a nuclear mechanism used by PKC-theta to mediate T cell gene expression. In this mode, PKC-theta tethers to chromatin to form an active nuclear complex by interacting with proteins including RNA polymerase II, the histone kinase MSK-1, the demethylase LS...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2012-08-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00260/full |