Chromatinised Protein Kinase C-theta: can it escape the clutches of NF-kB?

Chromatinised Protein Kinase C-theta: can it escape the clutches of NF-kB?

We recently provided the first description of a nuclear mechanism used by PKC-theta to mediate T cell gene expression. In this mode, PKC-theta tethers to chromatin to form an active nuclear complex by interacting with proteins including RNA polymerase II, the histone kinase MSK-1, the demethylase LS...

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Bibliographic Details
Main Authors: Elissa Lee Sutcliffe, Jasmine eLi, Anjum eZafar, Kristine eHardy, Reena eGhildyal, Robert eMcCuaig, Nicole eNorris, Chloe eLim, Peter J Milburn, Marco eCasarotto, Gareth eDenyer, Sudha eRao
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Immunology
Subjects:
Chromatin
microRNA
T cells
NF-kB
PKC-theta
signalling kinase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00260/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00260/full

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