Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing

Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing

Genetic mutations in TP53 contribute to multiple human cancers. Here we report the generation of a H1-p53(R248W/R248W) human embryonic stem cell line harboring a homozygous TP53 R248W mutation created by TALEN-mediated precise gene editing. The H1-p53(R248W/R248W) cell line maintains a normal karyot...

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Bibliographic Details
Main Authors: An Xu, Ruoji Zhou, Jian Tu, Zijun Huo, Dandan Zhu, Donghui Wang, Julian A. Gingold, Helen Mata, Pulivarthi H. Rao, Mo Liu, Alaa M.T. Mohamed, Celine Shuet Lin Kong, Brittany E. Jewell, Weiya Xia, Ruiying Zhao, Mien-Chie Hung, Dung-Fang Lee
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118301144

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http://www.sciencedirect.com/science/article/pii/S1873506118301144

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