Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

Abstract Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a variety of tumors, but resistance during treatment is a major issue. In this review, we describe the utility of PD-L1 expression levels, mutation burden, immune cell infiltration, and immune cell functio...

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Bibliographic Details
Main Authors: Daixi Ren, Yuze Hua, Boyao Yu, Xin Ye, Ziheng He, Chunwei Li, Jie Wang, Yongzhen Mo, Xiaoxu Wei, Yunhua Chen, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li, Yong Li, Zhaoyang Zeng, Wei Xiong
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Cancer
Subjects:
Cancer immunotherapy
Immune checkpoint blockade
PD-1/PD-L1
Immune cells
Precision medicine
Online Access:https://doi.org/10.1186/s12943-020-1144-6

Internet

https://doi.org/10.1186/s12943-020-1144-6

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