Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection

Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection

Abstract Background Hepatic stellate cell (HSC) activation plays a pivotal role in hepatic inflammation and liver fibrosis. TLR4 pathway activation has been reported to be involved in mice liver fibrosis induced by hepatitis virus infection, alcohol abuse, biliary ligation, carbon tetrachloride 4 tr...

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Bibliographic Details
Main Authors: Lan Chen, Xiaofang Ji, Manni Wang, Xiaoyan Liao, Cuiying Liang, Juanjuan Tang, Zhencheng Wen, Ferrandon Dominique, Zi Li
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Parasites & Vectors
Subjects:
TLR4 signaling
COX2/PGE2 axis
Liver fibrosis
Schistosoma japonicum
Online Access:https://doi.org/10.1186/s13071-021-04790-7

Internet

https://doi.org/10.1186/s13071-021-04790-7

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