A novel in vivo siRNA delivery system specifically targeting liver cells for protection of ConA-induced fulminant hepatitis.

A novel in vivo siRNA delivery system specifically targeting liver cells for protection of ConA-induced fulminant hepatitis.

Fulminant hepatitis progresses to acute liver failure (ALF) when the extent of hepatocyte death exceeds the liver's regenerative capacity. Although small interfering RNA (siRNA) appears promising in animal models of hepatitis, the approach is limited by drawbacks associated with systemic admini...

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Bibliographic Details
Main Authors: Nan Jiang, Xusheng Zhang, Xiufen Zheng, Di Chen, Kingsun Siu, Hongmei Wang, Thomas E Ichim, Douglas Quan, Vivian McAlister, Guihua Chen, Wei-Ping Min
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3435394?pdf=render

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http://europepmc.org/articles/PMC3435394?pdf=render

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