The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

Abstract Background Misfolding of microtubule-associated protein tau (MAPT) within neurons into neurofibrillary tangles is an important pathological feature of Alzheimer’s disease (AD). Tau pathology correlates with cognitive decline in AD and follows a stereotypical anatomical course; several recen...

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Bibliographic Details
Main Authors: Sarah C. Hopp, Yang Lin, Derek Oakley, Allyson D. Roe, Sarah L. DeVos, David Hanlon, Bradley T. Hyman
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Neuroinflammation
Subjects:
Tau
Microglia
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s12974-018-1309-z

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http://link.springer.com/article/10.1186/s12974-018-1309-z

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