The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease
Abstract Background Misfolding of microtubule-associated protein tau (MAPT) within neurons into neurofibrillary tangles is an important pathological feature of Alzheimer’s disease (AD). Tau pathology correlates with cognitive decline in AD and follows a stereotypical anatomical course; several recen...
Main Authors: | Sarah C. Hopp, Yang Lin, Derek Oakley, Allyson D. Roe, Sarah L. DeVos, David Hanlon, Bradley T. Hyman |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-09-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12974-018-1309-z |
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