MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2.

MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2.

Humoral immune responses initiate in the lymph node draining the site of viral infection (dLN). Some viruses subvert LN B cell activation; however, our knowledge of viral hindrance of B cell responses of important human pathogens is lacking. Here, we define mechanisms whereby chikungunya virus (CHIK...

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Bibliographic Details
Main Authors: Mary K McCarthy, Glennys V Reynoso, Emma S Winkler, Matthias Mack, Michael S Diamond, Heather D Hickman, Thomas E Morrison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008292

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https://doi.org/10.1371/journal.ppat.1008292

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