Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves

It is unclear what role calcium signalling plays in the Drosophila wing disc. Here, the authors show that on mechanical stress, slow, long-range intercellular calcium waves are initiated in vivo and ex vivo, mediated by the inositol-3-phosphate receptor, the calcium pump SERCA and gap junction compo...

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Bibliographic Details
Main Authors: Simon Restrepo, Konrad Basler
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12450