Heritability Estimation using a Regularized Regression Approach (HERRA): Applicable to continuous, dichotomous or age-at-onset outcome.

Heritability Estimation using a Regularized Regression Approach (HERRA): Applicable to continuous, dichotomous or age-at-onset outcome.

The popular Genome-wide Complex Trait Analysis (GCTA) software uses the random-effects models for estimating the narrow-sense heritability based on GWAS data of unrelated individuals without knowing and identifying the causal loci. Many methods have since extended this approach to various situations...

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Bibliographic Details
Main Authors: Malka Gorfine, Sonja I Berndt, Jenny Chang-Claude, Michael Hoffmeister, Loic Le Marchand, John Potter, Martha L Slattery, Nir Keret, Ulrike Peters, Li Hsu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5559077?pdf=render

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http://europepmc.org/articles/PMC5559077?pdf=render

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