An Integrated Proteomics and Bioinformatics Approach Reveals the Anti-inflammatory Mechanism of Carnosic Acid

An Integrated Proteomics and Bioinformatics Approach Reveals the Anti-inflammatory Mechanism of Carnosic Acid

Drastic macrophages activation triggered by exogenous infection or endogenous stresses is thought to be implicated in the pathogenesis of various inflammatory diseases. Carnosic acid (CA), a natural phenolic diterpene extracted from Salvia officinalis plant, has been reported to possess anti-inflamm...

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Bibliographic Details
Main Authors: Li-Chao Wang, Wen-Hui Wei, Xiao-Wen Zhang, Dan Liu, Ke-Wu Zeng, Peng-Fei Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
carnosic acid
anti-inflammatory
proteomics
MAPK pathway
IKKβ/IκB-α/NF-κB pathway
FoxO1/3 pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00370/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00370/full

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