TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes

TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes

Abstract Background Mesendodermal formation during early gastrulation requires the expression of lineage-specific genes, while the regulatory mechanisms during this process have not yet been fully illustrated. TATA box-binding protein (TBP) and TBP-like factors are general transcription factors resp...

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Bibliographic Details
Main Authors: He Liang, Peng Zhang, Hua-Jun Bai, Jijun Huang, Huang-Tian Yang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Stem Cell Research & Therapy
Subjects:
Human embryonic stem cells (hESCs)
TATA box-binding protein-related factor 3 (TRF3)
Mesendodermal differentiation
BRACHYURY (T)
EOMESODERMIN (EOMES)
Mix paired-like homeobox (MIXL1)
Online Access:http://link.springer.com/article/10.1186/s13287-020-01711-w

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http://link.springer.com/article/10.1186/s13287-020-01711-w

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