Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease.

Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease.

Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of Parkinson's disease (PD). To elucidate molecular mechanisms underlying neuronal dysfunction and alpha-synuclein pathology in the premotor phase of PD, we investigated the transcriptome of the substantia nigra...

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Bibliographic Details
Main Authors: Anke A Dijkstra, Angela Ingrassia, Renee X de Menezes, Ronald E van Kesteren, Annemieke J M Rozemuller, Peter Heutink, Wilma D J van de Berg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4472235?pdf=render

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http://europepmc.org/articles/PMC4472235?pdf=render

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