The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide.

The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide.

The deposition and oligomerization of amyloid β (Aβ) peptide plays a key role in the pathogenesis of Alzheimer's disease (AD). Aβ peptide arises from cleavage of the membrane-associated domain of the amyloid precursor protein (APP) by β and γ secretases. Several lines of evidence point to the s...

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Bibliographic Details
Main Authors: Jitka Petrlova, Tamás Kálai, Izumi Maezawa, Robin Altman, Ghimire Harishchandra, Hyun-Seok Hong, Daniel A Bricarello, Atul N Parikh, Gary A Lorigan, Lee-Way Jin, Kálmán Hideg, John C Voss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3340382?pdf=render

Internet

http://europepmc.org/articles/PMC3340382?pdf=render

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