Bias in recent miRBase annotations potentially associated with RNA quality issues

Abstract Although microRNAs are supposed to be stable in-vivo, degradation processes potentially blur our knowledge on the small oligonucleotides. We set to quantify the effect of degradation on microRNAs in mouse to identify causes for distorted microRNAs patterns. In liver, we found 298, 99 and 8...

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Bibliographic Details
Main Authors: Nicole Ludwig, Meike Becker, Timo Schumann, Timo Speer, Tobias Fehlmann, Andreas Keller, Eckart Meese
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05070-0