Parenterally Administered P24-VP8* Nanoparticle Vaccine Conferred Strong Protection against Rotavirus Diarrhea and Virus Shedding in Gnotobiotic Pigs

Current live rotavirus vaccines are costly with increased risk of intussusception due to vaccine replication in the gut of vaccinated children. New vaccines with improved safety and cost-effectiveness are needed. In this study, we assessed the immunogenicity and protective efficacy of a novel P24-VP...

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Bibliographic Details
Main Authors: Ashwin Ramesh, Jiangdi Mao, Shaohua Lei, Erica Twitchell, Ashton Shiraz, Xi Jiang, Ming Tan, and Lijuan Yuan
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/7/4/177