Heat shock protein 90 and calcineurin pathway inhibitors enhance the efficacy of triazoles against Scedosporium prolificans via induction of apoptosis

Heat shock protein 90 and calcineurin pathway inhibitors enhance the efficacy of triazoles against Scedosporium prolificans via induction of apoptosis

Scedosporium prolificans is a pathogenic mold resistant to current antifungals, and infection results in high mortality. Simultaneous targeting of both ergosterol biosynthesis and heat shock protein 90 (Hsp90) or the calcineurin pathway in S. prolificans may be an important strategy for enhancing th...

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Bibliographic Details
Main Authors: Fazal Shirazi, Dimitrios P. Kontoyiannis
Format: Article
Language:English
Published: Shared Science Publishers OG 2014-06-01
Series:Microbial Cell
Subjects:
apoptosis
17AAG
calcineurin
itraconazole
posaconazole
reactive oxygen species
Online Access:http://microbialcell.com/researcharticles/heat-shock-protein-90-and-calcineurin-pathway-inhibitors-enhance-the-efficacy-of-triazoles-against-scedosporium-prolificans-via-induction-of-apoptosis/

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http://microbialcell.com/researcharticles/heat-shock-protein-90-and-calcineurin-pathway-inhibitors-enhance-the-efficacy-of-triazoles-against-scedosporium-prolificans-via-induction-of-apoptosis/

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