A Combination of GM-CSF and Released Factors from Gamma-Irradiated Tumor Cells Enhances the Differentiation of Macrophages from Bone Marrow Cells and Their Antigen-Presenting Function and Polarization to Type 1

A Combination of GM-CSF and Released Factors from Gamma-Irradiated Tumor Cells Enhances the Differentiation of Macrophages from Bone Marrow Cells and Their Antigen-Presenting Function and Polarization to Type 1

Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes dendritic cell differentiation from precursors, and consequently, enhances the antigen presentation process and adaptive immune responses. With such functions, GM-CSF has been used as immunotherapy in combination with radiotherapy fo...

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Bibliographic Details
Main Authors: Lichao Chen, Shoji Imamichi, Ying Tong, Yuka Sasaki, Takae Onodera, Satoshi Nakamura, Hiroshi Igaki, Jun Itami, Mitsuko Masutani
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Medicines
Subjects:
GM-CSF
macrophage
radiotherapy
Online Access:https://www.mdpi.com/2305-6320/8/7/35

Internet

https://www.mdpi.com/2305-6320/8/7/35

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