Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy oncology trials as examples

Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy oncology trials as examples

Abstract Background Awareness of model-based designs for dose-finding studies such as the Continual Reassessment Method (CRM) is now becoming more commonplace amongst clinicians, statisticians and trial management staff. In some settings toxicities can occur a long time after treatment has finished,...

Full description

Bibliographic Details
Main Authors: Erik van Werkhoven, Samantha Hinsley, Eleni Frangou, Jane Holmes, Rosemarie de Haan, Maria Hawkins, Sarah Brown, Sharon B Love
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Medical Research Methodology
Subjects:
Phase I
Clinical trial design
TiTE-CRM
Late toxicity
Dose-finding
Adaptive trial design
Online Access:http://link.springer.com/article/10.1186/s12874-020-01012-z

Internet

http://link.springer.com/article/10.1186/s12874-020-01012-z

Similar Items