Synthesis and Cytotoxic Evaluation of 3-(4-Fluorophenyl)-4,5-dihydro-5-(3,4,5-trimethoxy/4-nitrophenyl)-N-(substituted-phenyl)pyrazole-1-carboxamide Analogues

Synthesis and Cytotoxic Evaluation of 3-(4-Fluorophenyl)-4,5-dihydro-5-(3,4,5-trimethoxy/4-nitrophenyl)-N-(substituted-phenyl)pyrazole-1-carboxamide Analogues

Abstract A novel series of 3-(4-fluorophenyl)-4,5-dihydro-5-(3,4,5-trimethoxy/4-nitro phenyl)-N-(substituted-phenyl)pyrazole-1-carboxamide analogues 4a–n was synthesized in two steps from 4-fluoroacetophenone. The pyrazoline analogues were evaluated for cytotoxicity against two breast cancer cell li...

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Bibliographic Details
Main Authors: Mohamed J. Ahsan, Bhawani S. Kumawat, Sonu Kumawat, Piush Sharma, Mohammad A. Bakht, Mohd Z. Hassan, Afzal Hussain, Pankaj Saraswat, Habibullah Khalilullah
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2018-04-01
Series:SynOpen
Subjects:
anticancer agents
breast cancer cell lines
mcf-7
mda-mb-231
srb assay
pyrazolines
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591980

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591980

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