The effects of the general anesthetic sevoflurane on neurotransmission: an experimental and computational study

Abstract The brain functions can be reversibly modulated by the action of general anesthetics. Despite a wide number of pharmacological studies, an extensive analysis of the cellular determinants of anesthesia at the microcircuits level is still missing. Here, by combining patch-clamp recordings and...

Full description

Bibliographic Details
Main Authors: Jonathan Mapelli, Daniela Gandolfi, Enrico Giuliani, Stefano Casali, Luigi Congi, Alberto Barbieri, Egidio D’Angelo, Albertino Bigiani
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83714-y