SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression

SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression

Abstract Atypical Teratoid Rhabdoid Tumor (AT/RT) is a rare pediatric central nervous system cancer often characterized by deletion or mutation of SMARCB1, a tumor suppressor gene. In this study, we found that SMARCB1 regulates Human Endogenous Retrovirus K (HERV-K, subtype HML-2) expression. HML-2...

Full description

Bibliographic Details
Main Authors: Tara T. Doucet-O’Hare, Brianna L. DiSanza, Catherine DeMarino, Abigail L. Atkinson, Jared S. Rosenblum, Lisa J. Henderson, Kory R. Johnson, Jeffrey Kowalak, Marta Garcia-Montojo, Sariah J. Allen, Brent A. Orr, Mariarita Santi, Tongguang Wang, Saeed Fathi, Myoung Hwa Lee, Kevon Sampson, Wenxue Li, Zhengping Zhuang, Avindra Nath
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92223-x

Internet

https://doi.org/10.1038/s41598-021-92223-x

Similar Items