TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells

TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells

Thioredoxin-interacting protein (TXNIP) plays a critical role in oxidative stress, inflammation, apoptosis and the pathogenesis of diabetic retinopathy (DR). However, the role of TXNIP in high glucose-induced retinal pigment epithelium (RPE) dysfunction is still unknown. Here, we show that high gluc...

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Bibliographic Details
Main Authors: Takhellambam S. Devi, Thangal Yumnamcha, Fayi Yao, Mallika Somayajulu, Renu A. Kowluru, Lalit P. Singh
Format: Article
Language:English
Published: The Company of Biologists 2019-04-01
Series:Biology Open
Subjects:
Hyperglycemia
TXNIP
Mitophagy
Lysosome destabilization
Retinal pigment epithelium
Online Access:http://bio.biologists.org/content/8/4/bio038521

Internet

http://bio.biologists.org/content/8/4/bio038521

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