Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO<sub>3</sub> Therapy in Murine Breast Tissue

Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO<sub>3</sub> Therapy in Murine Breast Tissue

The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO<sub>3</sub>-containing drinking water to female C57BL/6j...

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Bibliographic Details
Main Authors: Ninna C. S. Voss, Thomas Dreyer, Mikkel B. Henningsen, Pernille Vahl, Bent Honoré, Ebbe Boedtkjer
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
acidosis
buffer therapy
bicarbonate
mass spectrometry
pH
proteomics
Online Access:https://www.mdpi.com/2072-6694/12/4/891

Internet

https://www.mdpi.com/2072-6694/12/4/891

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