Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8 T-cell activation and exhaustion
CD8 + T-cell exhaustion is a dysfunctional state that is regulated through the expression of inhibitory checkpoint receptor genes including the cytotoxic T-lymphocyte–associated antigen 4, programmed death 1, and DNA methylation of effector genes interferon-γ, perforin, and granzyme B. Different str...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-03-01
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| Series: | Therapeutic Advances in Vaccines and Immunotherapy |
| Online Access: | https://doi.org/10.1177/2515135520904238 |