From Stem Cells to Populations—Using hiPSC, Next-Generation Sequencing, and GWAS to Explore the Genetic and Molecular Mechanisms of Congenital Heart Defects

From Stem Cells to Populations—Using hiPSC, Next-Generation Sequencing, and GWAS to Explore the Genetic and Molecular Mechanisms of Congenital Heart Defects

Congenital heart defects (CHD) are developmental malformations affecting the heart and the great vessels. Early heart development requires temporally regulated crosstalk between multiple cell types, signaling pathways, and mechanical forces of early blood flow. While both genetic and environmental f...

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Bibliographic Details
Main Authors: Martin Broberg, Johanna Hästbacka, Emmi Helle
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
congenital heart disease
genetics
genome-wide association studies
massively parallel sequencing
human induced pluripotent stem cells
Online Access:https://www.mdpi.com/2073-4425/12/6/921

Internet

https://www.mdpi.com/2073-4425/12/6/921

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