Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms

Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms

Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder in the ageing population. It is characterized by the cerebral accumulation of toxic amyloid-beta peptide assemblies (Aβ). The serine protease plasmin, which is generated from the inactive zymogen plasminogen through its p...

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Bibliographic Details
Main Authors: Mathias Cacquevel, Séverine Launay, Hervé Castel, Karim Benchenane, Simon Chéenne, Luc Buée, Lieve Moons, André Delacourte, Peter Carmeliet, Denis Vivien
Format: Article
Language:English
Published: Elsevier 2007-08-01
Series:Neurobiology of Disease
Subjects:
Tissue plasminogen activator
Ageing
Amyloid-beta peptides
Transgenic mice
Alzheimer’s disease
PAI-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000836

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http://www.sciencedirect.com/science/article/pii/S0969996107000836

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