Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions

Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions

Renal proximal tubular epithelial cells are significantly damaged during acute kidney injury. Renal proximal tubular cell-specific autophagy-deficient mice show increased sensitivity against renal injury, while showing few pathological defects under normal fed conditions. Considering that autophagy...

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Bibliographic Details
Main Authors: Chigure Suzuki, Isei Tanida, Juan Alejandro Oliva Trejo, Soichiro Kakuta, Yasuo Uchiyama
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
<i>atg7</i>
renal proximal tubular cell
gene knockout mouse
Online Access:https://www.mdpi.com/1422-0067/21/1/155

Internet

https://www.mdpi.com/1422-0067/21/1/155

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