Detection of NRAS mutation in cell-free DNA biological fluids from patients with kaposiform lymphangiomatosis

Detection of NRAS mutation in cell-free DNA biological fluids from patients with kaposiform lymphangiomatosis

Abstract Background Kaposiform lymphangiomatosis (KLA) has recently been distinguished as a novel subtype of generalized lymphatic anomaly (GLA) with foci of spindle endothelial cells. All cases of KLA involve multiple organs and have an unfavorable prognosis. However, the molecular pathogenesis is...

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Bibliographic Details
Main Authors: Michio Ozeki, Yoko Aoki, Akifumi Nozawa, Shiho Yasue, Saori Endo, Yumiko Hori, Kentaro Matsuoka, Tetsuya Niihori, Ryo Funayama, Matsuyuki Shirota, Keiko Nakayama, Toshiyuki Fukao
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Vascular anomaly
Kaposiform lymphangiomatosis
Neuroblastoma RAS viral oncogene homolog
Cell-free DNA
Liquid biopsy
Online Access:http://link.springer.com/article/10.1186/s13023-019-1191-5

Internet

http://link.springer.com/article/10.1186/s13023-019-1191-5

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