Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis

Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis

Thyromimetics, whose physicochemical characteristics are analog to thyroid hormones (THs) and their derivatives, are promising candidates as novel therapeutics for neurodegenerative and metabolic pathologies. In particular, sobetirome (GC-1), one of the initial halogen-free thyromimetics, and newly...

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Bibliographic Details
Main Authors: Bokyung Kim, Young Ho Ko, Massimiliano Runfola, Simona Rapposelli, Gabriella Ortore, Grazia Chiellini, Jin Hae Kim
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
transthyretin
thyromimetics
sobetirome
TTR amyloidosis
TTR stabilizers
protein aggregation
Online Access:https://www.mdpi.com/1422-0067/22/7/3488

Internet

https://www.mdpi.com/1422-0067/22/7/3488

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