Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)

Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)

Intestinal cancers are developed from intestinal epithelial stem cells (ISCs) in intestinal crypts through a multi-step process involved in genetic mutations of oncogenes and tumor suppressor genes. ISCs play a key role in maintaining the homeostasis of gut epithelium. In 2009, Sato et al establishe...

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Bibliographic Details
Main Authors: Xiaoxing Wu, Zhaoxia Li, Hongyu Zhang, Fang He, Min Qiao, Huaxiu Luo, Jing Zhang, Meng Zhang, Yukun Mao, William Wagstaff, Yongtao Zhang, Changchun Niu, Xia Zhao, Hao Wang, Linjuan Huang, Deyao Shi, Qing Liu, Na Ni, Kai Fu, Rex C. Haydon, Russell R. Reid, Hue H. Luu, Tong-Chuan He, Ziwei Wang, Houjie Liang, Bing-Qiang Zhang, Ning Wang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Genes and Diseases
Subjects:
Cancer modeling
Conditional immortalization
Mini-gut organoids
Mouse intestinal crypt (MIC) cells
Tumorigenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304221000118

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http://www.sciencedirect.com/science/article/pii/S2352304221000118

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