Detrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy.

Detrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy.

Temporal Lobe Epilepsy (TLE) is the most common type of epilepsy in adults where 20-30% of the patients are refractory to currently available anti-epileptic drugs. The RhoA/Rho-kinase signaling pathway activation has been involved in inflammatory responses, neurite outgrowth and neuronal death under...

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Bibliographic Details
Main Authors: NAZIM eKOURDOUGLI, Saara eVarpula, Genevieve eChazal, Claudio eRivera
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
KCC2
GABAergic transmission
Temporal Lobe Epilepsy
Astrogliosis
ROCK inhibitor
epilpetogenesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00413/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00413/full

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