Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

Histone acetylation is a critical process in the regulation of chromatin structure and gene expression. Histone deacetylases (HDACs) remove the acetyl group, leading to chromatin condensation and transcriptional repression. HDAC inhibitors are considered a new class of anticancer agents and have bee...

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Bibliographic Details
Main Authors: Danqi Chen, Aijun Shen, Guanghua Fang, Hongchun Liu, Minmin Zhang, Shuai Tang, Bing Xiong, Lanping Ma, Meiyu Geng, Jingkang Shen
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Histone deacetylases inhibitor
Anticancer
Tetrahydroisoquinoline
Structure–activity relationship
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515001598

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http://www.sciencedirect.com/science/article/pii/S2211383515001598

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