Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity

Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity

Adipose triglyceride lipase (ATGL) catalyzes the first step of triacylglycerol hydrolysis in adipocytes. Abhydrolase domain 5 (ABHD5) increases ATGL activity by an unknown mechanism. Prior studies have suggested that the expression of ABHD5 is limiting for lipolysis in adipocytes, as addition of rec...

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Bibliographic Details
Main Authors: Jorge M. Caviglia, Jenna L. Betters, Dianne-Helerie Dapito, Caleb C. Lord, Sean Sullivan, Streamson Chua, Terry Yin, Anna Sekowski, Haiyan Mu, Lawrence Shapiro, J. Mark Brown, Dawn L. Brasaemle
Format: Article
Language:English
Published: Elsevier 2011-11-01
Series:Journal of Lipid Research
Subjects:
adipose triglyceride lipase
triacylglycerol
macrophage
Toll-like receptor 4
abhydrolase domain 5
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350938

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http://www.sciencedirect.com/science/article/pii/S0022227520350938

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