Abnormal brain iron homeostasis in human and animal prion disorders.
Neurotoxicity in all prion disorders is believed to result from the accumulation of PrP-scrapie (PrP(Sc)), a beta-sheet rich isoform of a normal cell-surface glycoprotein, the prion protein (PrP(C)). Limited reports suggest imbalance of brain iron homeostasis as a significant associated cause of neu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-03-01
|
| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2652663?pdf=render |