Organ-Specific Expression of IL-1 Receptor Results in Severe Liver Injury in Type I Interferon Receptor Deficient Mice

Organ-Specific Expression of IL-1 Receptor Results in Severe Liver Injury in Type I Interferon Receptor Deficient Mice

Upon treatment with polyinosinic:polycytidylic acid [poly(I:C)], an artificial double-stranded RNA, type I interferon receptor-deficient (IFNAR−/−) mice develop severe liver injury seen by enhanced alanine aminotransferase (ALT) activity in the serum that is not observed in their wildtype (WT) count...

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Bibliographic Details
Main Authors: Martina Anzaghe, Theresa Resch, Elea Schaser, Stefanie Kronhart, Clara Diez, Marc A. Niles, Eugenia Korotkova, Stefan Schülke, Sonja Wolfheimer, Dorothea Kreuz, Marion Wingerter, María Matilde Bartolomé Rodríguez, Zoe Waibler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
anti-inflammatory
poly(I:C)
immune pathology
dysregulation
cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01009/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01009/full

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