Central Nervous System-Endogenous TLR7 and TLR9 Induce Different Immune Responses and Effects on Experimental Autoimmune Encephalomyelitis

Central Nervous System-Endogenous TLR7 and TLR9 Induce Different Immune Responses and Effects on Experimental Autoimmune Encephalomyelitis

Innate receptors, including Toll like receptors (TLRs), are implicated in pathogenesis of CNS inflammatory diseases such as multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). TLR response to pathogens or endogenous signals includes production of immunoregul...

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Bibliographic Details
Main Authors: Ruthe Storgaard Dieu, Vian Wais, Michael Zaucha Sørensen, Joanna Marczynska, Magdalena Dubik, Stephanie Kavan, Mads Thomassen, Mark Burton, Torben Kruse, Reza Khorooshi, Trevor Owens
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroscience
Subjects:
toll-like receptor
innate signaling
experimental autoimmune encephalomyelitis
monocytes
Type I interferons
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.685645/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.685645/full

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