IN VITRO IRREVERSIBLE BINDING AND DEGRADATION OF (R)- AND (S)-KETOPROFEN GLUCURONIDES TO PLASMA PROTEINS
This study describes the in vitro degradation studies of the diastereomeric ketoprofen glucuronides, under physiological conditions (pH 7.4, 37°C, (R)-ketoprofen glucuronide t½ = 30 min, (S)-ketoprofen glucuronide t½ = 70 min) and the irreversible binding of diastereomeric ketoprofen glucuronides (1...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universiti Sains Malaysia
2007-01-01
|
| Series: | Malaysian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.usm.my/mjps/MJPS%205%20(1)%202007/MJPS%205.1.5.pdf |