The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of voltage-gated ion channels (VGCs). Several studies s...

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Bibliographic Details
Main Authors: Jeffrey Lopez-Rojas, Maël Duménieu, Marie Oulé, Michael R. Kreutz
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
voltage-gated sodium channels
voltage-gated potassium channels
polarized trafficking
compartmentalization
voltage-gated ion channels
axon initial segment
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00115/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00115/full

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