Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

Human pluripotent stem cells (hPSCs) require precise control of post-transcriptional RNA networks to maintain proliferation and survival. Using enhanced UV crosslinking and immunoprecipitation (eCLIP), we identify RNA targets of the IMP/IGF2BP family of RNA-binding proteins in hPSCs. At the broad re...

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Bibliographic Details
Main Authors: Anne E. Conway, Eric L. Van Nostrand, Gabriel A. Pratt, Stefan Aigner, Melissa L. Wilbert, Balaji Sundararaman, Peter Freese, Nicole J. Lambert, Shashank Sathe, Tiffany Y. Liang, Anthony Essex, Severine Landais, Christopher B. Burge, D. Leanne Jones, Gene W. Yeo
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303230

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http://www.sciencedirect.com/science/article/pii/S2211124716303230

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