Renoprotective Action of a Matrix Metalloproteinase Inhibitor in Progressive Mesangioproliferative Nephritis

Renoprotective Action of a Matrix Metalloproteinase Inhibitor in Progressive Mesangioproliferative Nephritis

Background/Aim: Matrix metalloproteinases (MMPs) play pivotal roles in extracellular matrix turnover and are involved in chronic kidney disease. The renoprotective action of a synthetic MMP inhibitor, compound A, was investigated in chronic nephritis. Methods: Nephritis was induced by a single injec...

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Bibliographic Details
Main Authors: Takayuki Kuroda, Masao Masui, Mitsuru Notoya, Masashi Ito, Yoshinori Tamura, Hiroyuki Okamoto, Eri Kanaoka, Toshihiro Shinosaki
Format: Article
Language:English
Published: Karger Publishers 2012-05-01
Series:Nephron Extra
Subjects:
Matrix metalloproteinase-2
Glomerulonephritis
Glomerular basement membrane
Glomerular epithelial cells
Extracellular matrix
Online Access:http://www.karger.com/Article/FullText/338801

Internet

http://www.karger.com/Article/FullText/338801

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