Development of peptidomimetic ligands of Pro-Leu-Gly-NH2 as allosteric modulators of the dopamine D2 receptor

Development of peptidomimetic ligands of Pro-Leu-Gly-NH2 as allosteric modulators of the dopamine D2 receptor

A variety of stable, small-molecule peptidomimetic ligands have been developed to elucidate the mechanism by which the neuropeptide Pro-Leu-Gly-NH2 (PLG) modulates dopaminergic neurotransmission. Photoaffinity labeling ligands based upon PLG peptidomimetics have been used to establish that PLG binds...

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Bibliographic Details
Main Authors: Swapna Bhagwanth, Ram K. Mishra, Rodney L. Johnson
Format: Article
Language:English
Published: Beilstein-Institut 2013-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
allosteric modulation
dopamine D2 receptor
peptidomimetic
Pro-Leu-Gly-NH2
spiro-bicyclic scaffold
Online Access:https://doi.org/10.3762/bjoc.9.24

Internet

https://doi.org/10.3762/bjoc.9.24

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