Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

Parasites from the genus Plasmodium are the causative agents of malaria. The mobility, infectivity, and ultimately pathogenesis of Plasmodium falciparum rely on a macromolecular complex, called the glideosome. At the core of the glideosome is an essential and divergent Myosin A motor (PfMyoA), a fir...

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Bibliographic Details
Main Authors: Dihia Moussaoui, James P Robblee, Daniel Auguin, Elena B Krementsova, Silvia Haase, Thomas CA Blake, Jake Baum, Julien Robert-Paganin, Kathleen M Trybus, Anne Houdusse
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
malaria
mliding motility
erythrocytes invasion
myosin A
PfELC
antimalarial drugs
Online Access:https://elifesciences.org/articles/60581

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