Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum.

by Thomas C A Blake, Silvia Haase, Jake Baum
Published 2020-10-01

Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development

by Sujaan Das, Leandro Lemgruber, Chwen L. Tay, Jake Baum, Markus Meissner
Published 2017-08-01

Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions.

by Jake Baum, Alexander G Maier, Robert T Good, Ken M Simpson, Alan F Cowman
Published 2005-12-01

An inexpensive open source 3D-printed membrane feeder for human malaria transmission studies

by Kathrin Witmer, Ellie Sherrard-Smith, Ursula Straschil, Mark Tunnicliff, Jake Baum, Michael Delves
Published 2018-08-01

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

by Marion Koch, Jaimini Cegla, Ben Jones, Yuning Lu, Ziad Mallat, Andrew M. Blagborough, Fiona Angrisano, Jake Baum
Published 2019-11-01

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

by Wilson Wong, Xiao-chen Bai, Alan Brown, Israel S Fernandez, Eric Hanssen, Melanie Condron, Yan Hong Tan, Jake Baum, Sjors HW Scheres
Published 2014-06-01

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.

by Tony Triglia, Lin Chen, Sash Lopaticki, Chaitali Dekiwadia, David T Riglar, Anthony N Hodder, Stuart A Ralph, Jake Baum, Alan F Cowman
Published 2011-06-01

The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites.

by Kartik S Bane, Simone Lepper, Jessica Kehrer, Julia M Sattler, Mirko Singer, Miriam Reinig, Dennis Klug, Kirsten Heiss, Jake Baum, Ann-Kristin Mueller, Friedrich Frischknecht
Published 2016-07-01

Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

by Dihia Moussaoui, James P Robblee, Daniel Auguin, Elena B Krementsova, Silvia Haase, Thomas CA Blake, Jake Baum, Julien Robert-Paganin, Kathleen M Trybus, Anne Houdusse
Published 2020-10-01

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

by Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sánchez-Román Terán, Pedro L. Moura, Joseph Hawksworth, Jan Frayne, Ashley M. Toye, Jake Baum
Published 2019-08-01

An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum.

by Lin Chen, Sash Lopaticki, David T Riglar, Chaitali Dekiwadia, Alex D Uboldi, Wai-Hong Tham, Matthew T O'Neill, Dave Richard, Jake Baum, Stuart A Ralph, Alan F Cowman
Published 2011-09-01

Subcompartmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasite.

by Elizabeth S Zuccala, Alexander M Gout, Chaitali Dekiwadia, Danushka S Marapana, Fiona Angrisano, Lynne Turnbull, David T Riglar, Kelly L Rogers, Cynthia B Whitchurch, Stuart A Ralph, Terence P Speed, Jake Baum
Published 2012-01-01

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

by Hanwei Fang, Ana Rita Gomes, Natacha Klages, Paco Pino, Bohumil Maco, Eloise M. Walker, Zenon A. Zenonos, Fiona Angrisano, Jake Baum, Christian Doerig, David A. Baker, Oliver Billker, Mathieu Brochet
Published 2018-10-01

Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism

by Julien Robert-Paganin, James P. Robblee, Daniel Auguin, Thomas C. A. Blake, Carol S. Bookwalter, Elena B. Krementsova, Dihia Moussaoui, Michael J. Previs, Guillaume Jousset, Jake Baum, Kathleen M. Trybus, Anne Houdusse
Published 2019-07-01

Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum.

by Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman
Published 2013-01-01

A single-cell atlas of Plasmodium falciparum transmission through the mosquito

by Eliana Real, Virginia M. Howick, Farah A. Dahalan, Kathrin Witmer, Juliana Cudini, Clare Andradi-Brown, Joshua Blight, Mira S. Davidson, Sunil Kumar Dogga, Adam J. Reid, Jake Baum, Mara K. N. Lawniczak
Published 2021-05-01

Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

by Celia Miguel-Blanco, Irene Molina, Ana I. Bardera, Beatriz Díaz, Laura de las Heras, Sonia Lozano, Carolina González, Janneth Rodrigues, Michael J. Delves, Andrea Ruecker, Gonzalo Colmenarejo, Sara Viera, María S. Martínez-Martínez, Esther Fernández, Jake Baum, Robert E. Sinden, Esperanza Herreros
Published 2017-05-01

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

by Ellen Knuepfer, Katherine E Wright, Surendra Kumar Prajapati, Thomas A Rawlinson, Franziska Mohring, Marion Koch, Oliver R Lyth, Steven A Howell, Elizabeth Villasis, Ambrosius P Snijders, Robert W Moon, Simon J Draper, Anna Rosanas-Urgell, Matthew K Higgins, Jake Baum, Anthony A Holder
Published 2019-06-01

A high throughput screen for next-generation leads targeting malaria parasite transmission

by Michael J. Delves, Celia Miguel-Blanco, Holly Matthews, Irene Molina, Andrea Ruecker, Sabrina Yahiya, Ursula Straschil, Matthew Abraham, María Luisa León, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Jochen R. Brandt, Álvaro Cortés, Anna Barnard, Matthew J. Fuchter, Félix Calderón, Elizabeth A. Winzeler, Robert E. Sinden, Esperanza Herreros, Francisco J. Gamo, Jake Baum
Published 2018-09-01

The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957

by Celia Miguel-Blanco, James M. Murithi, Ernest Diez Benavente, Fiona Angrisano, Katarzyna A. Sala, Donelly A. van Schalkwyk, Manu Vanaerschot, Frank Schwach, Matthew J. Fuchter, Oliver Billker, Colin J. Sutherland, Susana G. Campino, Taane G. Clark, Andrew M. Blagborough, David A. Fidock, Esperanza Herreros, Francisco Javier Gamo, Jake Baum, Michael J. Delves
Published 2021-01-01