The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition

by Fu-Lien Hsieh, Matthew K Higgins
Published 2017-05-01

A Receptor's Tale: An Eon in the Life of a Trypanosome Receptor.

by Matthew K Higgins, Harriet Lane-Serff, Paula MacGregor, Mark Carrington
Published 2017-01-01

A rapid single-step centrifugation method for determination of HDL, LDL, and VLDL cholesterol, and TG, and identification of predominant LDL subclass

by Alex Sawle, Matthew K. Higgins, Marcus P. Olivant, Joan A. Higgins
Published 2002-02-01

Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor

by Harriet Lane-Serff, Paula MacGregor, Edward D Lowe, Mark Carrington, Matthew K Higgins
Published 2014-12-01

The structural basis for CD36 binding by the malaria parasite

by Fu-Lien Hsieh, Louise Turner, Jani Reddy Bolla, Carol V. Robinson, Thomas Lavstsen, Matthew K. Higgins
Published 2016-09-01

Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.

by Ashfaq Ghumra, Pongsak Khunrae, Ricardo Ataide, Ahmed Raza, Stephen J Rogerson, Matthew K Higgins, J Alexandra Rowe
Published 2011-01-01

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor

by Harriet Lane-Serff, Paula MacGregor, Lori Peacock, Olivia JS Macleod, Christopher Kay, Wendy Gibson, Matthew K Higgins, Mark Carrington
Published 2016-04-01

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis

by Kalyan S. Chakrabarti, Roman V. Agafonov, Francesco Pontiggia, Renee Otten, Matthew K. Higgins, Gebhard F.X. Schertler, Daniel D. Oprian, Dorothee Kern
Published 2016-01-01

Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein

by Natalie M. Barber, Clinton K. Y. Lau, Louise Turner, Gareth Watson, Susan Thrane, John P. A. Lusingu, Thomas Lavstsen, Matthew K. Higgins
Published 2021-02-01

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

by Frank Lennartz, Florian Brod, Rebecca Dabbs, Kazutoyo Miura, David Mekhaiel, Arianna Marini, Matthijs M. Jore, Max M. Søgaard, Thomas Jørgensen, Willem A. de Jongh, Robert W. Sauerwein, Carole A. Long, Sumi Biswas, Matthew K. Higgins
Published 2018-09-01

A helminth-derived suppressor of ST2 blocks allergic responses

by Francesco Vacca, Caroline Chauché, Abhishek Jamwal, Elizabeth C Hinchy, Graham Heieis, Holly Webster, Adefunke Ogunkanbi, Zala Sekne, William F Gregory, Martin Wear, Georgia Perona-Wright, Matthew K Higgins, Josquin A Nys, E Suzanne Cohen, Henry J McSorley
Published 2020-05-01

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

by Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Published 2020-03-01

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

by Ellen Knuepfer, Katherine E Wright, Surendra Kumar Prajapati, Thomas A Rawlinson, Franziska Mohring, Marion Koch, Oliver R Lyth, Steven A Howell, Elizabeth Villasis, Ambrosius P Snijders, Robert W Moon, Simon J Draper, Anna Rosanas-Urgell, Matthew K Higgins, Jake Baum, Anthony A Holder
Published 2019-06-01

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

by Paula MacGregor, Andrea L Gonzalez-Munoz, Fatoumatta Jobe, Martin C Taylor, Steven Rust, Alan M Sandercock, Olivia J S Macleod, Katrien Van Bocxlaer, Amanda F Francisco, Francois D'Hooge, Arnaud Tiberghien, Conor S Barry, Philip Howard, Matthew K Higgins, Tristan J Vaughan, Ralph Minter, Mark Carrington
Published 2019-05-01

Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens

by Joseph J. Illingworth, Daniel G. Alanine, Rebecca Brown, Jennifer M. Marshall, Helen E. Bartlett, Sarah E. Silk, Geneviève M. Labbé, Doris Quinkert, Jee Sun Cho, Jason P. Wendler, David J. Pattinson, Lea Barfod, Alexander D. Douglas, Michael W. Shea, Katherine E. Wright, Simone C. de Cassan, Matthew K. Higgins, Simon J. Draper
Published 2019-06-01