High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol

High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol

Abstract Autophagy is an intracellular recycling pathway with implications for intracellular homeostasis and cell survival. Its pharmacological modulation can aid chemotherapy by sensitizing cancer cells toward approved drugs and overcoming chemoresistance. Recent translational data on autophagy mod...

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Bibliographic Details
Main Authors: Jana Deitersen, Lena Berning, Fabian Stuhldreier, Sara Ceccacci, David Schlütermann, Annabelle Friedrich, Wenxian Wu, Yadong Sun, Philip Böhler, Niklas Berleth, María José Mendiburo, Sabine Seggewiß, Ruchika Anand, Andreas S. Reichert, Maria Chiara Monti, Peter Proksch, Björn Stork
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03830-5

Internet

https://doi.org/10.1038/s41419-021-03830-5

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