Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints

Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints

In this study, we sought to characterize synovial tissue obtained from individuals with arthralgia and disease-specific auto-antibodies and patients with established rheumatoid arthritis (RA), by applying an integrative multi-omics approach where we investigated differences at the level of DNA methy...

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Bibliographic Details
Main Authors: Andrew Y. F. Li Yim, Enrico Ferrero, Klio Maratou, Huw D. Lewis, George Royal, David F. Tough, Chris Larminie, Marcel M. A. M. Mannens, Peter Henneman, Wouter J. de Jonge, Marleen G. H. van de Sande, Danielle M. Gerlag, Rab K. Prinjha, Paul P. Tak
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
arthralgia
DNA methylation
transcriptomics
multi-omics analyses
synovial biopsies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.651475/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.651475/full

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